2020-02-29 · Hare et al. (2009) reported the promising result that among 112 trans women, a greater number of repeats of the CAG sequence were present in the androgen receptor (AR) gene compared to cisgender men. The authors note that this longer length results in androgens such as testosterone being less effective at activating the androgen receptor, possibly resulting in reduced brain masculinization

PubMed

The protein functions as a steroid-hormone activated transcription factor. 2021-04-18 · The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. 2017-04-15. Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response Androgen receptor (AR, alternative name NR3C4) belongs to the nuclear receptor (NR) superfamily. The human AR gene is located in the X chromosome at Xq11–12 and is encoded in eight exons.

We previously reported the identification of a novel AR coactivator protein, L-dopa decarboxylase (DDC), which can act at the cytoplasmic level to enhance AR activity. We Bi-directional Sanger sequencing of the gene Androgen Receptor is performed using PCR primers designed to target hotspot mutations in exons 4, 5 and 8. Clinical Significance Androgen receptor (AR) is a ligand-dependent transcription factor that plays a critical role in the development and progression of prostate cancer. Numerous studies have shown an association between polymorphisms in the androgen receptor gene (AR) and the risk for androgenetic alopecia (AGA), but the overall results are still controversial. Aim. To determine, by conducting a meta‐analysis, whether the common AR gene polymorphisms confer susceptibility to AGA. Methods. Polymorphic variation in the androgen receptor gene: association with risk of testicular germ cell cancer and metastatic disease. Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift discovered.€The€androgen€receptor€gene€(AR)€is€known€to€be€altered€in€several€ways during€PC€progression.€Thus,AR€is€believed€to€be€the€one€of€the€major€contributors€to the€emergence€of€CRPC.

We previously reported the identification of a novel AR coactivator protein, L-dopa decarboxylase (DDC), which can act at the cytoplasmic level to enhance AR activity. We Bi-directional Sanger sequencing of the gene Androgen Receptor is performed using PCR primers designed to target hotspot mutations in exons 4, 5 and 8.

Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024).

In the rat gubernaculum (5) and penis (6), changes in the tissue content of androgen receptor are correlated Possible association between the androgen receptor gene and autism spectrum disorder. Research output: Contribution to journal › Article Nevertheless, recent reports suggest that mutations in the androgen-receptor gene can occur in androgen-independent prostate cancer. 18,19,21 In this report we show that in 5 of 10 patients with 2015-05-15 Numerous studies have shown an association between polymorphisms in the androgen receptor gene (AR) and the risk for androgenetic alopecia (AGA), but the overall results are still controversial. Aim. To determine, by conducting a meta‐analysis, whether the common AR gene polymorphisms confer susceptibility to AGA. Methods.

The AR gene provides instructions for making a protein called an androgen receptor. Androgens are hormones (such as testosterone) that are important for normal male sexual development before birth and during puberty. Androgen receptors allow the body to respond appropriately to these hormones.

Belongs to the nuclear hormone receptor family. NR3 subfamily.

The AR, when bound by a ligand, complexes with DNA at androgen response elements in the promoter region of target genes. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Welcome to the Androgen Receptor Gene Mutations Database World Wide Web Server.
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Diseases associated with AR include Androgen Insensitivity, Partial and Spinal And Bulbar Muscular Atrophy, X-Linked 1 . Among its related pathways are Notch-mediated HES/HEY network and Androgen receptor signaling pathway . The human androgen receptor (AR) is a protein encoded by a gene located on the proximal long arm of the X chromosome (locus Xq11-Xq12). The protein coding region consists of approximately 2,757 nucleotides (919 codons) spanning eight exons, designated 1-8 or A-H. Introns vary in size between 0.7 and 26 kb.

The androgen receptor (AR) is a nuclear receptor that functions as a transcription factor and regulates the development and growth of the prostate. The AR, when bound by a ligand, complexes with DNA at androgen response elements in the promoter region of target genes. The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain.
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Purpose: Although novel agents targeting the androgen–androgen receptor (AR) axis have altered the treatment paradigm of metastatic castration-resistant prostate cancer (mCRPC), development of therapeutic resistance is inevitable. In this study, we examined whether AR gene aberrations detectable in circulating cell-free DNA (cfDNA) are associated with resistance to abiraterone acetate and

Transcription activation is also down-regulated by The androgen receptor (AR) is a nuclear receptor that functions as a transcription factor and regulates the development and growth of the prostate. The AR, when bound by a ligand, complexes with DNA at androgen response elements in the promoter region of target genes. The androgen receptor (AR) mediates the effects of male sex steroids.